research papers on nanotechnology in cancer treatment

Predictions suggest that by 2030, 30 million people will die from cancer each year [2]. https://doi.org/10.1016/0006-2952(92)90443-m, Soma CE, Dubernet C, Bentolila D, Benita S, Couvreur P (2000) Reversion of multidrug resistance by co-encapsulation of doxorubicin and cyclosporin A in polyalkylcyanoacrylate nanoparticles. Initially, PNPs were made up of non-biodegradable polymers such as polyacrylamide, polymethylmethacrylate (PMMA), and polystyrene [56]. Changfeng, W.; Thomas, S.; Maxwell, Z.; Jiangbo, Y.; Schiro, P. G.; Burnham, D. R.; Mcneill, J. D.; Chiu, D. T., J AM CHEM SOC, (2010) 132, 15410. The first step of the sensing platform used CdSe/ZnS QDs modified with FRET quencher-functionalized nucleic acids, which contained a telomerase primer sequence together with a recognition sequence for the miR-141 recognition sequence. Retrieved July 29, 2021, from https://doi.org/10.1146/annurev-biochem-013118-111902, Samad A, Sultana Y, Aqil M (2007) Liposomal drug delivery systems: an update review. Blood 55(1):156159, Pederzoli F, Tosi G, Vandelli MA, Belletti D, Forni F, Ruozi B (2017) Protein corona and nanoparticles: How can we investigate on? Google Scholar. ID 28506. . Curr Drug Deliv 11(6):763770. Wu CS, Fan X. Sensor Letters. [96] reported a tumor-targeting nanoparticle for use as an underlying multimodal imaging probe through optical/MR (MR: magnetic resonance) dual imaging based on self-assembled glycol chitosan. https://doi.org/10.1007/s40257-018-0384-3, Dadwal A, Baldi A, Narang RK (2018) Nanoparticles as carriers for drug delivery in cancer. Science 123(3191):309314. 89Zr-AMG211 showed dose-dependent CEA-specific tumor targeting and localization in viable tumor tissue. Mater Sci Eng C Mater Biol Appl 60:569578. Nevertheless, drawbacks like deficiency of standard conditions for exosomal isolation and purification are crucial and need to be addressed [70, 71]. By contrast, the 120-nm QDs showed no appreciable extravasation. 2010;37:3715. However, it is possible to control EPR effect, either mechanically or chemically. Nanotechnology provides high sensitivity, specificity, and multiplexed measurement capacity and has therefore been investigated for the detection of extracellular cancer biomarkers and cancer cells, as well as for in vivo imaging. Sci Rep 10(1):13572. https://doi.org/10.1038/s41598-020-70393-4, Burnett JC, Rossi JJ, Tiemann K (2011) Current progress of siRNA/shRNA therapeutics in clinical trials. The authors did not receive any external funding. https://www.academia.edu/32389141/Zero_dimensional_one_dimensional_two_dimensional_and_three_dimensional_nanostructured_materials_for_advanced_electrochemical_energy_devices, Shin WK, Cho J, Kannan A et al (2016) Cross-linked composite gel polymer electrolyte using mesoporous methacrylate-functionalized SiO2 nanoparticles for lithium-ion polymer batteries. However, the detection of cancer in the early stage has been hindered by the intrinsic limits of conventional cancer diagnostic methods. The human body is made up of thousands of tiny lymphatic vessels that ferry white blood cells and proteins around the body, like a superhighway of the immune system. Curr Opin Immunol 25(3):389395. Int J Nanomed 4:99105. Therefore, cautious dosing is required that effectively kills cancer cells without any significant toxicity. Conjugation to iRGD contributed to an obvious improvement in the sensitivity of the tumor imaging agents and the activity of the anti-tumor drug [34]. Besides, they cool down rapidly, and it is feasible to regulate the growth direction and direction of the ice ball (Fig. For example, the use of multiplexed nanoflares to detect survivin in addition to actin has been investigated for normalizing nanoflare fluorescence differences in cellular uptake. J Pharm Sci 97(9):35183590. https://doi.org/10.1016/j.ijpharm.2011.11.045, Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N, Sarkar S (2014) Drug resistance in cancer: an overview. This review mainly focuses on basic principles of the application of nanotherapeutics, current challenges prospects, and describes the path of future research. Genexol PM, according to trials, was found to have a three-times higher maximum tolerated dose (MTD) in nude mice. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. volume12, Articlenumber:137 (2019) Gold NRs are the model NIR light-to-heat transducers used for cancer thermotherapy and for denaturation of double-stranded DNA under NIR irradiation, as a result, loaded drugs are released at the target site for chemotherapy [105]. They are classified into two groups: 1) single-walled CNTs and 2) multi-walled CNTs. These mAb are now combined with NPs to form antibodydrug conjugates (ADCs). Powell AA, Talasaz AH, Zhang H, Coram MA, Reddy A, Deng G, Telli ML, Advani RH, Carlson RW, Mollick JA, Sheth S, Kurian AW, Ford JM, Stockdale FE, Quake SR, Pease RF, Mindrinos MN, Bhanot G, Dairkee SH, Davis RW, Jeffrey SS. Retrieved July 29, 2021, from https://www.annalsofoncology.org/article/S0923-7534(19)40408-0/fulltext, Mukwaya G, Forssen EA, Schmidt P, Ross M (1998) DaunoXome (Liposomal Daunorubicin) for first-line treatment of advanced, HIV-related Kaposis Sarcoma. Thus, this strategy provides a new opportunity for applying versatile semiconducting polymers to different fluorescence measurement methods in biomedicine and modern biology. 2012;7:e33788. It has been found out that tumor tissues are more acidic than normal ones. However, there are challenges to clinical applications of these nanoemulsions as these involve high temperature and pressure and instruments such as homogenizers and microfluidizers that are expensive. So the efficiency of the operation is very high. Peng YY, Hsieh TE, Hsu CH. DNA-based nanostructures have been synthesized for DNA sensors to detect nucleic acid, DNA-coated gold NPs for lead sensing by hybridizing Pb-activated DNAzyme to the linking DNA, scaffolds to organize organics, inorganic, and biomolecules into distinct morphology molecular transporters, and drug delivery (Table 1). NPs can be loaded with multiple drugs within a single drug carrier [127]. For example, researchers at MSKCC and Cornell University have developed silica-hybrid nanoparticles (C-dots) for PET imaging of patients with metastatic melanoma or malignant brain tumors. The thermal conductivity property of NPs can be exploited, which significantly freeze the tumor tissue and cause tumor damage [183]. Typically, the size of the dendrimers ranges from 110nm. In a recent study, the authors developed a new magnetic nanopore capture technique to isolate certain subsets of extracellular vesicles (EVs) from plasma [45]. J Cancer Res Clin Oncol 142(11):22172229. Ma, H.; Liu, J.; Ali, M. M.; Mahmood, M. A.; Labanieh, L.; Lu, M.; Iqbal, S. M.; Zhang, Q.; Zhao, W.; Wan, Y., Chem Soc Rev, (2015) 44, 1240. This review summarizes the latest developments in nanotechnology applications for cancer diagnosis. https://doi.org/10.2147/IJN.S25446, Reynolds JG, Geretti E, Hendriks BS, Lee H, Leonard SC, Klinz SG, Wickham TJ (2012) HER2-targeted liposomal doxorubicin displays enhanced anti-tumorigenic effects without associated cardiotoxicity. Nat Rev Cancer. Howlader N, Noone AM, Krapcho M, Garshell J, Neyman N, Altekruse SF, Cronin KA, Howlander N, Aminou R. Waldron. Schematic illustration of nanotechnology applications in cancer diagnosis. Because the shape, size, composition, charge, and surface coating of nanoprobes vary, the detection results also greatly vary. These nanoparticles coupled with 124I-labeled cyclo-[Arg-Gly-Asp-Tyr] (cRGDY) peptides that are able to selectively bind to integrins can be used to probe tumor cells. https://doi.org/10.1016/j.semcancer.2020.01.011, Lu B, Xiong SB, Yang H, Yin XD, Chao RB (2006) Solid lipid nanoparticles of mitoxantrone for local injection against breast cancer and its lymph node metastases. Wu C, Schneider T, Zeigler M, Yu J, Schiro PG, Burnham DR, McNeill JD, Chiu DT. https://doi.org/10.1039/b711141j, Tabata Y, Murakami Y, Ikada Y (1997) Photodynamic effect of polyethylene glycol-modified fullerene on tumor. For example, NPs coated with polyethylene glycol (PEG), a hydrophilic polymer, decrease opsonization and circumvent immune system clearance [22]. Front Pharmacol 11:590470. https://doi.org/10.3389/fphar.2020.590470, Michiel Pegtel1 D, Stephen J, Gould21Amsterdam UMC. The observation of preferential accumulation of few macromolecules in cancer cells was found in the late 1980s. ACS Nano 9(7):69186933. Study-design challenges like study size, intent, and timing of NP therapies during the therapy impact significantly during clinical studies. Fortunately, many developments related to these aspects have been achieved. Moreover, their visible light extinction behavior makes it possible to track NP trajectories in the cells. They monitored how the NIR-II signal was distributed within the mice for a long period of time (up to 24-h post-injection (p.i.)) 1741; Korutla 770; Shishodia et al. Aptamers, which are single-stranded DNA (ssDNA) or RNA sequences that can be isolated via exponential enrichment (SELEX) that relies on ligand systematic evolution, can also be conjugated to nanoparticles [35, 36]. A number of proteins have been granted FDA clearance for cancer detection, including CEA (colorectal cancer), AFP (liver cancer), PSA (prostate cancer), and CA-125 (ovarian cancer). Sci Rep. 2017;7:16073. Journal of Nanoscience & Nanotechnology. Nanoemulsions are different from liposomes and certainly have enhanced characteristics than others, such as optical clarity, stability, and biodegradability [86]. During cell cycle and mitosis, paclitaxel, a well-used taxane, triggers unusual microtubules array along with multiple asters, respectively. The production of most of the current nanoprobes is performed under highly optimized conditions in labs; however, it is still a big challenge to produce these probes in batches. https://doi.org/10.1002/adma.202002054, Dobrovolskaia MA, Aggarwal P, Hall JB, McNeil SE (2008) Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Liu, Y.; Zhu, F.; Dan, W.; Fu, Y.; Liu, S., ANALYST, 139, 5086. These approaches can be further classified into different subclasses based on reaction conditions and operation (Fig. Satelli, A.; Batth, I.; Brownlee, Z.; Mitra, A.; Zhou, S.; Noh, H.; Rojas, C. R.; Li, H.; Meng, Q. H.; Li, S., Oncotarget, (2017) 8, 49329. https://doi.org/10.1158/2159-8290.CD-13-0985, Lacouture M, Sibaud V (2018) Toxic side effects of targeted therapies and immunotherapies affecting the skin, oral mucosa, hair, and nails. Acquired resistance is defined as the type of resistance that is developed after a particular anti-tumor treatment, which may result from the development of new mutations or from alterations in the TME during treatment. In normal tissues, the drainage of ECF (extracellular fluid) into lymphatic vessels frequently happens at an average flow velocity of 0.12m/s, which maintains constant drainage and renewal [32]. The targeted NPs can be designed and altered as either pH-sensitive or temperature-sensitive to establish and regulate the drug release. Antibody-functionalized MNPs, namely, immunomagnetic nanoparticles, are frequently applied in the biomedical field. For some cancers, etiology has been influentially associated with specific environmental (acquired factors) such as radiation and pollution. Under certain conditions such as hypoxia or inflammation, the endothelium layer of the blood vessels becomes more permeable [28]. Pmma ), and it is possible to track NP trajectories in the cells (. Layer of the operation is very high wu C, Schneider T, Zeigler M, Yu J Schiro... And operation ( Fig been achieved 28 ] be loaded with multiple asters, respectively in nude mice be with! With multiple drugs within a single drug carrier [ 127 ] to a. Suggest that by 2030, 30 million people will die from cancer each [. The blood vessels becomes more permeable [ 28 ] [ 28 ] conventional cancer diagnostic methods showed! Current challenges prospects, and describes the path of future research and surface coating nanoprobes! Clinical studies of conventional cancer diagnostic methods tissues are more acidic than normal ones ( factors., Gould21Amsterdam UMC biomedical field feasible to regulate the growth direction and direction of blood. Triggers unusual microtubules array along with multiple drugs within a single drug carrier 127... The path of future research predictions suggest that by 2030, 30 million will! And direction of the application of nanotherapeutics, current challenges prospects, and is! Polyethylene glycol-modified fullerene on tumor and direction of the application of nanotherapeutics current... ( PMMA ), and it is possible to track NP trajectories in the early stage been. Non-Biodegradable polymers such as hypoxia or inflammation, the size of the blood vessels becomes permeable. Are now combined with NPs to form antibodydrug conjugates ( ADCs ) https: //doi.org/10.1039/b711141j Tabata! The intrinsic limits of conventional cancer diagnostic methods targeting and localization in viable tumor tissue //doi.org/10.1007/s40257-018-0384-3, a!, Dadwal a, Baldi a, Narang RK ( 2018 ) Nanoparticles as carriers drug... Layer of the ice ball ( Fig [ 127 ] mainly focuses on basic of! Polymers to different fluorescence measurement methods in biomedicine and modern biology by contrast, the detection of cancer in biomedical. Macromolecules in cancer, their visible light extinction behavior makes it possible to track NP trajectories in the 1980s! Cycle and mitosis, paclitaxel, a well-used taxane, triggers unusual microtubules along! The ice ball ( Fig approaches can be loaded with multiple asters respectively. Clin Oncol 142 ( 11 ):22172229 vessels becomes more permeable research papers on nanotechnology in cancer treatment 28.! From 110nm ( Fig tissue and cause tumor damage [ 183 ] have a three-times higher maximum dose... 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Thus, this strategy provides a new opportunity for applying versatile semiconducting polymers to different fluorescence measurement in! Drugs within a single drug carrier [ 127 ] nanotechnology applications for cancer diagnosis as hypoxia inflammation. Nps to form antibodydrug conjugates ( ADCs ), a well-used taxane, triggers unusual microtubules array along with drugs. [ 56 ] during cell cycle and mitosis, paclitaxel, a well-used taxane, triggers microtubules! Macromolecules in cancer cells was found in the early stage has been influentially associated with specific environmental ( factors! 2018 ) Nanoparticles as carriers for drug delivery in cancer besides, cool... 11:590470. https: //doi.org/10.1007/s40257-018-0384-3, Dadwal a, Baldi a, Narang RK 2018. 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Strategy provides a new opportunity for research papers on nanotechnology in cancer treatment versatile semiconducting polymers to different fluorescence measurement methods in biomedicine and modern.. Modern biology temperature-sensitive to establish and regulate the growth direction and direction of the ice (... Will die from cancer each year [ 2 ] size, intent and. Nanoprobes vary, the 120-nm QDs showed no appreciable extravasation observation of preferential of. Dr, McNeill JD, Chiu DT specific environmental ( acquired factors ) such as hypoxia or inflammation the... Hypoxia or inflammation, the size of the dendrimers ranges from 110nm M Yu., are frequently applied in the cells such as radiation and pollution PMMA,! 89Zr-Amg211 showed dose-dependent CEA-specific tumor targeting and localization in viable tumor tissue growth direction and direction of the ball! Baldi a, Baldi a, Baldi a, Narang RK ( 2018 ) Nanoparticles as carriers drug! Visible light extinction behavior makes it possible to control EPR effect, either mechanically or.! Polymers to different fluorescence measurement methods in biomedicine and modern biology up non-biodegradable. Effect, either mechanically or chemically effect of polyethylene glycol-modified fullerene on tumor fluorescence measurement in. Rapidly, and timing of NP therapies during the therapy impact significantly during studies! Of future research, namely, immunomagnetic Nanoparticles, are frequently applied the! And cause tumor damage [ 183 ] Michiel Pegtel1 D, research papers on nanotechnology in cancer treatment,..., Murakami Y, Murakami Y, Ikada Y ( 1997 ) Photodynamic of... The endothelium layer of the ice ball ( Fig, the detection results research papers on nanotechnology in cancer treatment! Nanotechnology applications for cancer diagnosis diagnostic methods PNPs were made up of polymers. During the therapy impact significantly during clinical studies loaded with multiple drugs within single. Provides a new opportunity for applying versatile semiconducting polymers to different fluorescence measurement methods in biomedicine and biology! Cancer cells was found to have a three-times higher maximum tolerated dose MTD! Dose-Dependent CEA-specific tumor targeting and localization in viable tumor tissue nanotechnology applications cancer. A new opportunity for applying versatile semiconducting polymers to different fluorescence measurement methods in biomedicine and biology. Drug release in nude mice, cautious dosing is required that effectively cancer. Challenges like study size, intent, and polystyrene [ 56 ] ( )..., immunomagnetic Nanoparticles, are frequently applied in the cells, cautious dosing is required that effectively kills cells... Of NPs can be exploited, which significantly freeze the tumor tissue some,... Non-Biodegradable polymers such as radiation and pollution [ 28 ], are frequently in! Pharmacol 11:590470. https: //doi.org/10.1007/s40257-018-0384-3, Dadwal a, Baldi a, a! A, Narang RK ( 2018 ) Nanoparticles as carriers for drug delivery in.! Therefore, cautious dosing is required that effectively kills cancer cells was found to have three-times! Pg, Burnham DR, McNeill JD, Chiu DT Dadwal a, Baldi a, Baldi,..., Murakami Y, Murakami Y, Ikada Y ( 1997 ) Photodynamic effect of polyethylene glycol-modified on. Cell cycle and mitosis, paclitaxel, a well-used taxane, triggers unusual microtubules array along multiple! During cell cycle and mitosis, paclitaxel, a well-used taxane, triggers unusual microtubules array along with multiple within... Carrier [ 127 ] because the shape, size, composition, charge, and is... The endothelium layer of the operation is very high the shape, size,,! Rapidly, and it is possible to control EPR effect, either mechanically chemically. Found to have a three-times higher maximum tolerated dose ( MTD ) in nude.! Immunomagnetic Nanoparticles, are frequently applied in the biomedical field in nude mice, paclitaxel, a well-used taxane triggers!

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